Excess body weight and specific types of depressive symptoms: Is there a mediating role of systemic low-grade inflammation?

ABSTRACT:

Objectives

Obesity is associated with an increased risk of depression. Systemic low-grade inflammation, a plausible consequence of obesity, has also been linked to depression. However, the potential mediating effects of systemic low-grade inflammation on the association between excess body weight and specific symptom domains of depression remain uncertain. This study examined whether systemic low-grade inflammation mediated the associations of excess body weight (overweight and obesity) with subsequent overall, cognitive-affective, and somatic depressive symptoms.

Design

This study used a prospective cohort design.

Methods

The final analytical sample included 4,942 adults aged ≥50 years drawn from the English Longitudinal Study of Ageing (ELSA). Body mass index (BMI)

SUBMITTER: Chu K 

PROVIDER: S-EPMC10567582 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature