Causality between heart failure and epigenetic age: a bidirectional Mendelian randomization study.

ABSTRACT:

Aims

Heart failure (HF) is a prevalent age-related cardiovascular disease with poor prognosis in the elderly population. This study aimed to establish the causal relationship between ageing and HF by conducting a bidirectional Mendelian randomization (MR) analysis on epigenetic age (a marker of ageing) and HF.

Methods and results

Genome-wide association study data for epigenetic age (GrimAge, HorvathAge, HannumAge, and PhenoAge) and HF were collected and assessed for significant genetic variables. A bidirectional MR analysis was carried out using the random-effects inverse-variance weighted (IVW) method as the primary approach, while other methods (MR-Egger, weighted median, simple mode, and weighted mode) and multiple sensitivity analyses (heterogeneity analysis, leave-one-

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10567637 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature