Genetic structure and kdr mutations in Aedes aegypti populations along a road crossing the Amazon Forest in Amapa State, Brazil.

ABSTRACT: Insecticide resistance in Aedes aegypti poses a significant threat to disease control. One form of resistance, caused by kdr mutations in the Na_V gene, hinders vector control efforts in Brazil. Despite genetic differences typically accumulating among isolated populations, this mosquito can actively and passively disperse through human transportation. Our study investigated the genetic structure and spread of kdr mutations in Ae. aegypti populations across six localities in Amapá State, Brazil, within the Amazonian Forest. Using 12 microsatellite loci and qPCR methods, we assessed genetic structure and identified three common kdr mutations (V410L, V1016I, and F1534C). High prevalence of kdr alleles was observed in all localities, indicating widespread distribution in Amapá State.

SUBMITTER: Souza BS 

PROVIDER: S-EPMC10567682 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature