Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.

ABSTRACT: The immunoglobulin (Ig) superfamily members are involved in cell adhesion and migration, complex multistep processes that play critical roles in embryogenesis, wound healing, tissue formation, and many other processes, but their specific functions during embryonic development remain unclear. Here, we have studied the function of the immunoglobulin superfamily member 3 (IGSF3) by generating an Igsf3 knockout (KO) mouse model with CRISPR/Cas9-mediated genome engineering. By combining RNA and protein detection methodology, we show that during development, IGSF3 localizes to the neural crest and a subset of its derivatives, suggesting a role in normal embryonic and early postnatal development. Indeed, inactivation of Igsf3 impairs the ability of the vagal neural crest cells to migrate and norm

SUBMITTER: Tanjore Ramanathan J 

PROVIDER: S-EPMC10567708 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature