The effect of random virus failure following cell entry on infection outcome and the success of antiviral therapy.

ABSTRACT: A virus infection can be initiated with very few or even a single infectious virion, and as such can become extinct, i.e. stochastically fail to take hold or spread significantly. There are many ways that a fully competent infectious virion, having successfully entered a cell, can fail to cause a productive infection, i.e. one that yields infectious virus progeny. Though many stochastic models (SMs) have been developed and used to estimate a virus infection's establishment probability, these typically neglect infection failure post virus entry. The SM presented herein introduces parameter [Formula: see text] which corresponds to the probability that a virion's entry into a cell will result in a productive cell infection. We derive an expression for the likelihood of infection establishment

SUBMITTER: Quirouette C 

PROVIDER: S-EPMC10567758 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature