Dataset Information

Behavior of higher-order MDD on energy ratios at the interface of thermoelastic and piezothermoelastic mediums.

ABSTRACT: This paper investigates the intricate energy distribution patterns emerging at an orthotropic piezothermoelastic half-space interface by considering the influence of a higher-order three-phase lags heat conduction law, accompanied by memory-dependent derivatives (referred to as HPS) within the underlying thermoelastic half-space (referred to as TS). This study explores the amplitude and energy ratios of reflected and transmitted waves. These waves span various incident types, including longitudinal, thermal, and transversal, as they propagate through the TS and interact at the interface. Upon encountering the interface, an intriguing dynamic unfolds: three waves experience reflection within the TS medium, while four waves undergo transmission into the HPS medium. A graphical representation effectively illustrates the impact of higher-order time differential parameters and memory to offer comprehensive insights. This visual representation reveals the nuanced fluctuations of energy ratios with the incidence angle. The model astutely captures diverse scenarios, showcasing its ability to interpret complex interface dynamics.

SUBMITTER: Barak MS

PROVIDER: S-EPMC10567774 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Behavior of higher-order MDD on energy ratios at the interface of thermoelastic and piezothermoelastic mediums.

Barak M S MS Ahmad Hijaz H Kumar Rajesh R Kumar Rajneesh R Gupta Vipin V Awwad Fuad A FA Ismail Emad A A EAA

Scientific reports 20231011 1

This paper investigates the intricate energy distribution patterns emerging at an orthotropic piezothermoelastic half-space interface by considering the influence of a higher-order three-phase lags heat conduction law, accompanied by memory-dependent derivatives (referred to as HPS) within the underlying thermoelastic half-space (referred to as TS). This study explores the amplitude and energy ratios of reflected and transmitted waves. These waves span various incident types, including longitudi ...[more]

PMID: 37821492

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Project description:It is increasingly being recognized that physical interactions between distant chromosomal loci influence the expressivity of the genome. Thus, multiple enhancers may converge on a single gene promoter 1,2 and a single enhancer can stochastically loop to multiple promoters 3. Regulatory elements from neighboring domains or from other chromosomes may interact to generate chromatin structures poised for transcription4-8 or repression 9-11. However, a broader perspective on the formation and function of such networks remains largely unexplored. Using the high-resolution 4C (Circular Chromosome Conformation Capture) analysis, we identify here a genome-wide physical network between genomically imprinted domains impinging H19 imprinting control region (ICR). Sequences interacting with the H19 ICR constitutively map at or within most of known imprinted domains both in mouse embryonic stem cells and in vitro-derived embryoid bodies, despite distinct differences in chromatin environments. Moreover, all-to-all 3D DNA FISH analyses revealed that imprinted domains from 7 different chromosomes co-localize with each other in pair-wise patterns, highlighting the dynamic nature of these interactions. The observed interaction network is dependent on CTCF binding sites within the maternally inherited H19 ICR allele and delays reprogramming of epigenetic features at imprinted domains during male germline development. As other imprinted regions can interact with each other in an H19 ICR-dependent manner, the H19 ICR emerges as an organizer of chromosomal networks by specifically recognizing and reconfiguring imprinted domains. We propose that an ancient key regulatory region, such as the H19 ICR, gradually impacted epigenetic modifications via long-range interactions in the germline to facilitate the recruitment of imprinted genes and their formation in clusters during mammalian radiation. Furthermore, the perspective of epigenetic lesions de-stabilizing such chromosomal networks may advance our understanding of how quantitative traits influence human diseases, such as cancer.

Dataset Information

Behavior of higher-order MDD on energy ratios at the interface of thermoelastic and piezothermoelastic mediums.

Publications

Behavior of higher-order MDD on energy ratios at the interface of thermoelastic and piezothermoelastic mediums.

Similar Datasets

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