Metabolomics investigation of post-mortem human pericardial fluid.

ABSTRACT:

Introduction

Due to its peculiar anatomy and physiology, the pericardial fluid is a biological matrix of particular interest in the forensic field. Despite this, the available literature has mainly focused on post-mortem biochemistry and forensic toxicology, while to the best of authors' knowledge post-mortem metabolomics has never been applied. Similarly, estimation of the time since death or post-mortem interval based on pericardial fluids has still rarely been attempted.

Objectives

We applied a metabolomic approach based on ¹H nuclear magnetic resonance spectroscopy to ascertain the feasibility of monitoring post-mortem metabolite changes on human pericardial fluids with the aim of building a multivariate regression model for post-mortem interval estimation.

SUBMITTER: Chighine A 

PROVIDER: S-EPMC10567860 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature