Impact of cannabis use on brain metabolism using ³¹P and ¹H magnetic resonance spectroscopy.

ABSTRACT:

Purpose

This prospective cross-sectional study investigated the influence of regular cannabis use on brain metabolism in young cannabis users by using combined proton and phosphorus magnetic resonance spectroscopy.

Methods

The study was performed in 45 young cannabis users aged 18-30, who had been using cannabis on a regular basis over a period of at least 2 years and in 47 age-matched controls. We acquired 31P MRS data in different brain regions at 3T with a double-resonant 1H/31P head coil, anatomic images, and 1H MRS data with a standard 20-channel 1H head coil. Absolute concentration values of proton metabolites were obtained via calibration from tissue water as an internal reference, whereas a standard solution of 75 mmol/l KH2PO4 was used as an external reference for t

SUBMITTER: Fenzl M 

PROVIDER: S-EPMC10567915 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature