Emulating Target Trials Comparing Early and Delayed Intubation Strategies.

ABSTRACT:

Background

Whether intubation should be initiated early in the clinical course of critically ill patients remains a matter of debate. Results from prior observational studies are difficult to interpret because of avoidable flaws including immortal time bias, inappropriate eligibility criteria, and unrealistic treatment strategies.

Research question

Do treatment strategies that intubate patients early in the critical care admission improve 30-day survival compared with strategies that delay intubation?

Study design and methods

We estimated the effect of strategies that require early intubation of critically ill patients compared with those that delay intubation. With data extracted from the Medical Information Mart for Intensive Care-IV database, we emulated three targ

SUBMITTER: Wanis KN 

PROVIDER: S-EPMC10567927 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature