Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis.

ABSTRACT:

Background

IV fluids are recommended for adults with sepsis. However, the optimal strategy for IV fluid management in sepsis is unknown, and clinical equipoise exists.

Research question

Do lower vs higher fluid volumes improve patient-important outcomes in adult patients with sepsis?

Study design and methods

We updated a systematic review with meta-analysis and trial sequential analysis of randomized clinical trials assessing lower vs higher IV fluid volumes in adult patients with sepsis. The coprimary outcomes were all-cause mortality, serious adverse events, and health-related quality of life. We followed the recommendations from the Cochrane Handbook and used the Grading of Recommendations Assessment, Development and Evaluation approach. Primary conclusions were ba

SUBMITTER: Sivapalan P 

PROVIDER: S-EPMC10567931 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature