Coordinated Priming of NKG2D Pathway by IL-15 Enhanced Functional Properties of Cytotoxic CD4⁺CD28^- T Cells Expanded in Systemic Lupus Erythematosus.

ABSTRACT: Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder, and numerous aberrations of T cell responses have been reported and were implicated in its pathophysiology. Recently, CD4-positive T cells with cytotoxic potential were shown to be involved in autoimmune disease progression and tissue damage. However, the effector functions of this cell type and their potential molecular mechanisms in SLE patients remain to be elucidated. In this study, we find that cytotoxic CD4⁺CD28^- T cells are expanded in SLE patients with flow cytometry analysis, and the percentage of CD4⁺CD28^- T cells positively correlates with the Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI). Furthermore, our study suggests that interleukin-1

SUBMITTER: Wang T 

PROVIDER: S-EPMC10567942 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature