A Reappraisal of the Effects of L-type Ca²⁺ Channel Blockers on Store-Operated Ca²⁺ Entry and Heart Failure.

ABSTRACT: Dihydropyridines such as amlodipine are widely used as antihypertensive agents, being prescribed to ∼70 million Americans and >0.4 billion adults worldwide. Dihydropyridines block voltage-gated Ca²⁺ channels in resistance vessels, leading to vasodilation and a reduction in blood pressure. Various meta-analyses show that dihydropyridines are relatively safe and effective in reducing hypertension. The use of dihydropyridines has recently been called into question as these drugs appear to activate store-operated Ca²⁺ entry in fura-2-loaded nonexcitable cells, trigger vascular remodeling, and increase heart failure, leading to the questioning of their clinical use. Given that hypertension is the dominant "silent killer" across the globe affecting ∼1.13 billion people, rem

SUBMITTER: Bird GS 

PROVIDER: S-EPMC10568199 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature