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A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism.

ABSTRACT: We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an Escherichia coli strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs.

SUBMITTER: Blanchard A 

PROVIDER: S-EPMC10568403 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism.

Blanchard Aude A   Abramov Mikhail M   Hassan Camille C   Marlière Philippe P   Herdewijn Piet P   Pezo Valérie V  

RSC advances 20231012 43

We explored the toxicity and mutagenicity of a wide range of xenobiotic nucleoside triphosphates to an <i>Escherichia coli</i> strain equipped with a nucleoside triphosphate transporter. This bacterial test provides a tool to evaluate and guide the synthesis of nucleotides for applications such as the propagation of non-natural genetic information or the selection of potential drugs. ...[more]