Macrophage RIPK3 triggers inflammation and cell death via the XBP1-Foxo1 axis in liver ischaemia-reperfusion injury.

ABSTRACT:

Background & aims

Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a central player in triggering necroptotic cell death. However, whether macrophage RIPK3 may regulate NOD1-dependent inflammation and calcineurin/transient receptor potential cation channel subfamily M member 7 (TRPM7)-induced hepatocyte death in oxidative stress-induced liver inflammatory injury remains elusive.

Methods

A mouse model of hepatic ischaemia-reperfusion (IR) injury, the primary hepatocytes, and bone marrow-derived macrophages were used in the myeloid-specific RIPK3 knockout (RIPK3^M-KO) and RIPK3-proficient (RIPK3^FL/FL) mice.

Results

RIPK3^M-KO diminished IR stress-induced liver damage with reduced serum alanine aminotransferase/aspartate am

SUBMITTER: Qu X 

PROVIDER: S-EPMC10568422 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature