Design and Synthesis of Pyrimidine Amine Containing Isothiazole Coumarins for Fungal Control.

ABSTRACT: Developing new fungicides is always crucial to protecting crops. A series of 4-(3,4-dichloroisothiazol-5-yl)-7-(2-((5-(5-pyrimidin-4-yl)amino)ethoxy)-8-methyl) coumarin derivatives were designed and synthesized by Williamson ether condensation and substitution reactions. Structure determinations were clarified by ¹H NMR, ¹³C NMR, and HRMS, and compound 4h crystallized by the fusion method for further structural confirmation. The in vitro bioassay results showed that the target compounds displayed good fungicidal activity against Alternaria solani, Botrytis cinerea, Cercospora arachidicola, Fusarium graminearum, Physalospora piricola, Rhizoctonia solani, and Sclerotinia sclerotiorum. Among them, compounds 4b

SUBMITTER: Li K 

PROVIDER: S-EPMC10568580 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature