Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID).

ABSTRACT:

Introduction

Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT) can prevent severe infections but not underlying immune dysregulation.

Methods

In this study, we evaluated the serum concentrations of proinflammatory (TNF-α, IL-1β, IL-6) and immunoregulatory cytokines (IL-10), as well as lipopolysaccharide (LPS) and soluble CD14 (sCD14) in CVID individuals with infectious only (INF-CVID), and those with additional systemic autoimmune and inflammatory disorders (NIC-CVID), and healthy donors (HD).

Results

Our results showed increased serum concentrations of TNF-α, IL-1β, IL-6, and

SUBMITTER: Poto R 

PROVIDER: S-EPMC10568625 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature