Hesperidin Attenuates Titanium Dioxide Nanoparticle-Induced Neurotoxicity in Rats by Regulating Nrf-2/TNF-α Signaling Pathway, the Suppression of Oxidative Stress, and Inflammation.

ABSTRACT: Background: Titanium dioxide nanoparticles (TiO₂NPs) are widely utilized and consumed mainly as food additives. Oxidative stress is considered to be the basic effect of TiO₂NPs through biological interactions. Hesperidin (HSP) is a bioflavonoid (flavanone glycoside) with lipid-lowering, inflammation, oxidative stress suppression, antihypertensive, cancer-fighting, and antiedema effects. Objective: This study was to investigate the possible protective influences of HSP of subchronic oral TiO₂NP exposure on the brains of rats, including neurotransmitters, oxidative stress/antioxidant parameters, inflammatory markers, and histological changes in the brains of adult male albino rats. Methodology: The experiment was executed on 80 albino rat

SUBMITTER: Eid A 

PROVIDER: S-EPMC10568688 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature