Drug treatment for oral submucous fibrosis: an update.

ABSTRACT:

Objective

The aim of this review is to evaluate the different medicinal interventions available for the management of oral submucous fibrosis (OSF).

Materials and methods

We conducted a comprehensive electronic search on PubMed, Web of Science, and Cochrane Library databases for articles related to OSF patients treated with medications from December 2011 to September 2022. GRADE system was used to evaluate the evidence quality. The reporting of the systematic review is in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The main outcomes were the improvement of maximum mouth opening, burning sensation, cheek flexibility, and tongue protrusion.

Results

Twenty-nine randomized controlled trials (RCTs), five clinica

SUBMITTER: Chen X 

PROVIDER: S-EPMC10568776 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature