Plasma hepatocyte growth factor as a noninvasive biomarker in small cell lung cancer.

ABSTRACT:

Background

Hepatocyte growth factor (HGF) is a peptide-containing multifunctional cytokine, which is overexpressed and/or activated in multiple malignancies and is reported to be associated with tumor development and inferior survival. At present, the role of HGF in small cell lung cancer (SCLC) has not been fully explored yet.

Materials and methods

The expression of HGF and its value in predicting survival in SCLC were explored from GEO database and in pan-cancer analysis. Furthermore, we detected the expression of HGF using tumor tissue and paired plasma samples from a validation cohort of 71 SCLC patients at our institute. Correlation between tumor and plasma HGF expression and the prognostic values were analyzed.

Results

GEO database analysis revealed that tumor t

SUBMITTER: Zhao C 

PROVIDER: S-EPMC10568809 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature