Sequence-based GWAS meta-analyses for beef production traits.

ABSTRACT:

Background

Combining the results of within-population genome-wide association studies (GWAS) based on whole-genome sequences into a single meta-analysis (MA) is an accurate and powerful method for identifying variants associated with complex traits. As part of the H2020 BovReg project, we performed sequence-level MA for beef production traits. Five partners from France, Switzerland, Germany, and Canada contributed summary statistics from sequence-based GWAS conducted with 54,782 animals from 15 purebred or crossbred populations. We combined the summary statistics for four growth, nine morphology, and 15 carcass traits into 16 MA, using both fixed effects and z-score methods.

Results

The fixed-effects method was generally more informative to provide indication on potentially

SUBMITTER: Sanchez MP 

PROVIDER: S-EPMC10568825 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature