Jin-Gui-Shen-Qi Wan ameliorates diabetic retinopathy by inhibiting apoptosis of retinal ganglion cells through the Akt/HIF-1α pathway.

ABSTRACT:

Background

Jin-Gui-Shen-Qi Wan (JGSQ) has been used in China for thousands of years to treat various ailments, including frequent urination, blurred vision, and soreness in the waist and knees. It has traditional therapeutic advantages in improving eye diseases.

Aim of the study

Clinical studies have confirmed the therapeutic efficacy of JGSQ in improving diabetes and vision; however, its efficacy and pharmacological effects in treating diabetic retinopathy (DR) remain unclear. Therefore, the aim of this study was to investigate the specific pharmacological effects and potential mechanisms of JGSQ in improving DR through a db/db model.

Materials and methods

db/db mice were given three different doses of orally administered JGSQ and metformin for 8 weeks, and then PAS

SUBMITTER: Liang D 

PROVIDER: S-EPMC10568827 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature