Model containing sarcopenia and visceral adiposity can better predict the prognosis of hepatocellular carcinoma: a multicenter study.

ABSTRACT:

Aim

This study aimed to explore whether the addition of sarcopenia and visceral adiposity could improve the accuracy of model predicting progression-free survival (PFS) in hepatocellular carcinoma (HCC).

Methods

In total, 394 patients with HCC from five hospitals were divided into the training and external validation datasets. Patients were initially treated by liver resection or transarterial chemoembolization. We evaluated adipose and skeletal muscle using preoperative computed tomography imaging and then constructed three predictive models, including metabolic (Model^MA), clinical-imaging (Model^CI), and combined (Model^MA-CI) models. Their discrimination, calibration, and decision curves were compared, to identify the best model. Nomogram an

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10568831 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature