The role of creatine kinase in distinguishing generalized tonic-clonic seizures from psychogenic non-epileptic seizures (PNES) and syncope: a retrospective study and meta-analysis of 1300 patients.

ABSTRACT:

Background/aim

As the clinical differentiation between epileptic seizures, psychogenic non-epileptic seizures (PNES), and syncope depends mainly on a detailed report of the event, which may not be available, an objective assessment of a potential biochemical analysis is needed. We aimed to investigate whether serum creatine kinase (CK) could be used to differentiate epileptic seizure from PNES and syncope and to assess the strength of evidence present.

Methods

We directed a retrospective cohort study coupled with a systematic review and meta-analysis of studies that measured CK in patients with epilepsy, PNES, syncope, and healthy controls.

Results

The cohort study, which traced 202 patients, showed that the CK level was significantly higher 48 h after the event in th

SUBMITTER: Abdelnaby R 

PROVIDER: S-EPMC10568853 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature