Dataset Information

MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib.

ABSTRACT:

Background

The immune microenvironment within hepatocellular carcinoma (HCC) is remarkably intricate. Although the combination of an immune checkpoint inhibitor and Lenvatinib can extend the overall survival of HCC patients, the outcome remains suboptimal.

Methods

We assessed alterations in MEX3C expression during hepatocarcinogenesis by validating multiple databases and subsequently developed a predictive model. Subsequently, we enriched the associated genes of MEX3C to investigate its functional role. We examined the correlation between MEX3C expression levels and immune infiltrating cells. The effects of MEX3C knockdown and Lenvatinib on hepatoma cells were observed by cell function experiments.

Results

MEX3C expression is elevated in HCC compared to normal tissues, and its high expression correlates with poor prognosis. Immune checkpoint expression was elevated in the high MEX3C expression group, concomitant with heightened myeloid-derived suppressor cell (MDSC) expression. The combination of MEX3C knockdown and Lenvatinib demonstrated a stronger inhibitory effect on HCC cells compared to Lenvatinib alone.

Conclusion

MEX3C shows promise as a potential therapeutic target for treating HCC. Furthermore, the combination of MEX3C knockdown and Lenvatinib could offer a novel therapeutic avenue for HCC treatment.

SUBMITTER: Guo J

PROVIDER: S-EPMC10568896 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib.

Guo Jinhui J Zhao Jie J Xu Qiuran Q Huang Dongsheng D

BMC cancer 20231012 1

<h4>Background</h4>The immune microenvironment within hepatocellular carcinoma (HCC) is remarkably intricate. Although the combination of an immune checkpoint inhibitor and Lenvatinib can extend the overall survival of HCC patients, the outcome remains suboptimal.<h4>Methods</h4>We assessed alterations in MEX3C expression during hepatocarcinogenesis by validating multiple databases and subsequently developed a predictive model. Subsequently, we enriched the associated genes of MEX3C to investiga ...[more]

PMID: 37828435

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Dataset Information

MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib.

Background

Methods

Results

Conclusion

Publications

MEX3C as a potential target for hepatocellular carcinoma drug and immunity: combined therapy with Lenvatinib.

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