The early life immune dynamics and cellular drivers at single-cell resolution in lamb forestomachs and abomasum.

ABSTRACT:

Background

Four-chambered stomach including the forestomachs (rumen, reticulum, and omasum) and abomasum allows ruminants convert plant fiber into high-quality animal products. The early development of this four-chambered stomach is crucial for the health and well-being of young ruminants, especially the immune development. However, the dynamics of immune development are poorly understood.

Results

We investigated the early gene expression patterns across the four-chambered stomach in Hu sheep, at 5, 10, 15, and 25 days of age. We found that forestomachs share similar gene expression patterns, all four stomachs underwent widespread activation of both innate and adaptive immune responses from d 5 to 25, whereas the metabolic function were significantly downregulated with age.

SUBMITTER: Huang K 

PROVIDER: S-EPMC10568933 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature