Binding of Stimuli-Responsive Ruthenium Aqua Complexes with 9-Ethylguanine.

ABSTRACT: Stimuli-responsive ruthenium complexes proximal- and distal-[Ru(C₁₀tpy)(C₁₀pyqu) OH₂]²⁺ (proximal-1 and distal-1; C₁₀tpy = 4'-decyloxy-2,2':6',2″-terpyridine and C₁₀pyqu = 2-[2'-(6'-decyloxy)-pyridyl]quinoline) were experimentally studied for adduct formation with a model DNA base. At 303 K, proximal-1 exhibited 1:1 adduct formation with 9-ethylguanine (9-EtG) to yield proximal-[Ru(C₁₀tpy)(C₁₀pyqu)(9-EtG)]²⁺ (proximal-RuEtG). Rotation of the guanine ligand on the ruthenium center was sterically hindered by the presence of an adjacent quinoline moiety at 303 K. Results from ¹H NMR measurements indicated tha

SUBMITTER: Maeda A 

PROVIDER: S-EPMC10569010 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature