Elucidating Sequence-Assembly Relationships for Bilingual PNA Biopolymers.

ABSTRACT: Nucleic acids and proteins possess encoded "languages" that can be used for information storage or to direct function. However, each biopolymer is limited to encoding its respective "language." Using a peptide nucleic acid (PNA) scaffold, nucleobase and amino acid residues can be installed on a singular backbone, enabling a single biopolymer to encode both languages. Our laboratory previously reported the development of a "bilingual" PNA biopolymer that incorporates a sequence-specific nucleic acid code interspersed with hydrophobic (alanine) and hydrophilic (lysine) amino acid residues at defined positions to produce amphiphilic character. We observed the amphiphilic amino acid residues directing the biopolymer to undergo self-assembly into micelle-like structures, while the nucleic acid

SUBMITTER: Argueta-Gonzalez H 

PROVIDER: S-EPMC10569013 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature