Recruitment of C4b-binding protein is not a complement evasion strategy employed by Staphylococcus aureus.

ABSTRACT: Complement offers a first line of defence against infection through the opsonization of microbial pathogens, recruitment of professional phagocytes to the infection site and the coordination of inflammatory responses required for the resolution of infection. Staphylococcus aureus is a successful pathogen that has developed multiple mechanisms to thwart host immune responses. Understanding the precise strategies employed by S. aureus to bypass host immunity will be paramount for the development of vaccines and or immunotherapies designed to prevent or limit infection. To gain a better insight into the specific immune evasion mechanisms used by S. aureus we examined the pathogen's interaction with the soluble complement inhibitor, C4b-binding protein (C4BP). Previous stu

SUBMITTER: Li S 

PROVIDER: S-EPMC10569063 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature