Chronic antigen in solid tumors drives a distinct program of T cell residence.

ABSTRACT: Analyses of healthy tissue reveal signatures that identify resident memory CD8⁺ T cells (T_RM), which survey tissues without recirculating. The density of T_RM phenotype cells within solid tumors correlates favorably with prognosis, suggesting that intratumoral residents control cancer. However, residence has not been directly tested, and intratumoral T_RM phenotype cells could instead reflect aspects of the microenvironment that correlate with prognosis. Using a breast cancer model in mice, we found that conventional T_RM markers do not inform the tumor residence of either bystander or tumor-specific cells, which exhibit further distinct phenotypes in the tumor microenvironment and healthy mammary tissue. Rather, tumor-specific, stem prog

SUBMITTER: Gavil NV 

PROVIDER: S-EPMC10569081 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature