PH-Responsive Upconversion Mesoporous Silica Nanospheres for Combined Multimodal Diagnostic Imaging and Targeted Photodynamic and Photothermal Cancer Therapy.

ABSTRACT: Photodynamic therapy (PDT) and photothermal therapy (PTT) have gained considerable attention as potential alternatives to conventional cancer treatments. However, these approaches remain limited by low solubility, poor stability, and inefficient targeting of many common photosensitizers (PSs) and photothermal agents (PTAs). To overcome the aforementioned limitations, we engineered biocompatible and biodegradable tumor-targeted upconversion nanospheres with imaging capabilities. The multifunctional nanospheres consist of a sodium yttrium fluoride core doped with lanthanides (ytterbium, erbium, and gadolinium) and the PTA bismuth selenide (NaYF₄:Yb/Er/Gd,Bi₂Se₃) enveloped in a mesoporous silica shell that encapsulates a PS, chlorin e6 (Ce6), within its pores.

SUBMITTER: Palanikumar L 

PROVIDER: S-EPMC10569106 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature