Predictors of long-term disability in multiple sclerosis patients using routine magnetic resonance imaging data: A 15-year retrospective study.

ABSTRACT:

Introduction

Early identification of patients at high risk of progression could help with a personalised treatment strategy. Magnetic resonance imaging (MRI) measures have been proposed to predict long-term disability in multiple sclerosis (MS), but a reliable predictor that can be easily implemented clinically is still needed.

Aim

Assess MRI measures during the first 5 years of the MS disease course for the ability to predict progression at 10+ years.

Methods

Eighty-two MS patients (53 females), with ≥10 years of clinical follow-up and having two MRI scans, were included. Clinical data were obtained at baseline, follow-up and at ≥10 years. White matter lesion (WML) counts and volumes, and four linear brain sizes were measured on T2/FLAIR 'Fluid-Attenuated-Inversion-R

SUBMITTER: Altokhis A 

PROVIDER: S-EPMC10569198 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature