Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development.

ABSTRACT:

Background and aims

An interactive regulatory network assembled through the induction and downregulation of distinct transcription factors governs acinar cell maturation. Understanding how this network is built is relevant for protocols of directed pancreatic acinar differentiation. The murine transcription factor Prox1 is highly expressed in multipotent pancreatic progenitors and in various mature pancreatic cell types except for acinar cells. In this study, we investigated when is Prox1 expression terminated in developing acinar cells and the potential involvement of its activity in acinar cell specification/differentiation. We also investigated the effects of sustained Prox1 expression in acinar maturation and maintenance.

Methods

Prox1 acinar expression was analyzed by i

SUBMITTER: Martinez-Ramirez AS 

PROVIDER: S-EPMC10569262 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature