Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most common sustained arrhythmia, and it causes a high rate of complications such as stroke. It is known that AF begins as paroxysmal form and gradually progresses to persistent form, and sometimes it is difficult to identify paroxysmal AF (PAF) before having stroke. The aim of this study is to evaluate the risk of PAF and stroke using genetic analysis and circulating biomarkers.

Materials and methods

A total of 600 adult subjects were enrolled (300 from PAF and control groups). Peripheral blood was drawn to identify the genetic variation and biomarkers. Ten single nucleotide polymorphisms (SNPs) were analyzed, and circulating cell-free DNA (cfDNA) was measured from plasma. Four microRNAs (miR-99a-5p, miR-192-5p, miR-214-3p, and miR

SUBMITTER: Sasano T 

PROVIDER: S-EPMC10569505 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature