Epidemiology and risk factors of Japanese encephalitis in Taiwan, 2010-2022.

ABSTRACT:

Introduction

Taiwan introduced a two-dose inactivated Japanese encephalitis (JE) mouse brain-derived (JE-MB) vaccine into routine childhood immunization in 1968, with booster vaccination implemented in 1974 and 1983. In 2017, JE-MB vaccine was replaced by a two-dose live-attenuated chimeric vaccine (JE-CV). After implementation of JE vaccination programs, JE cases have shifted from children to adults. In this study, we described the JE epidemiology and identify high-risk groups to further inform vaccine policy.

Methodology/principal findings

We extracted data from Taiwan's notifiable disease surveillance database, vital statistics, and employment statistics from 2010 to 2022. Diagnosis of JE was confirmed by JE seroconversion, a four-fold increase in virus-specific antibodie

SUBMITTER: Hsu JY 

PROVIDER: S-EPMC10569588 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature