First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody.

ABSTRACT: With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is important for studying their role in immune response and memory. This study presents the first use of dynamic positron emission tomography (PET) and kinetic modeling for in vivo measurement of CD8⁺ T cell biodistribution in humans. A ⁸⁹Zr-labeled CD8-targeted minibody (⁸⁹Zr-Df-Crefmirlimab) was used with total-body PET in healthy individuals (N = 3) and coronavirus disease 2019 (COVID-19) convalescent patients (N = 5). Kinetic modeling results aligned with T cell-trafficking effects expected in lymphoid organs. Tissue-to-blood ratios from the first 7 hours of imaging were higher in b

SUBMITTER: Omidvari N 

PROVIDER: S-EPMC10569706 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature