One size does not fit all - Trehalose metabolism by Clostridioides difficile is variable across the five phylogenetic lineages.

ABSTRACT: Clostridioides difficile, the leading cause of antibiotic-associated diarrhoea worldwide, is a genetically diverse species which can metabolise a number of nutrient sources upon colonising a dysbiotic gut environment. Trehalose, a disaccharide sugar consisting of two glucose molecules bonded by an α 1,1-glycosidic bond, has been hypothesised to be involved in the emergence of C. difficile hypervirulence due to its increased utilisation by the RT027 and RT078 strains. Here, growth in trehalose as the sole carbon source was shown to be non-uniform across representative C. difficile strains, even though the genes for its metabolism were induced. Growth in trehalose reduced the expression of genes associated with toxin production and sporulation in the C. difficile

SUBMITTER: Marshall A 

PROVIDER: S-EPMC10569727 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature