Molecular characterization of <i>Streptococcus pneumoniae</i> causing disease among children in Nigeria during the introduction of PCV10 (GSK).

ABSTRACT: Streptococcus pneumoniae (pneumococcus) is a leading vaccine-preventable cause of childhood invasive disease. Nigeria has the second highest pneumococcal disease burden globally, with an estimated ~49 000 child deaths caused by pneumococcal infections each year. Ten-valent pneumococcal conjugate vaccine (GSK; PCV10) was introduced in December 2014 in a phased approach. However, few studies have characterized the disease-causing pneumococci from Nigeria. This study assessed the prevalence of serotypes, antibiotic susceptibility and genomic lineages using whole genome sequencing and identified lineages that could potentially escape PCV10 (GSK). We also investigated the potential differences in pneumococcal lineage features between children with and without sickle cell disease.

SUBMITTER: Lo SW 

PROVIDER: S-EPMC10569732 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature