Acquisition of Type I methyltransferase via horizontal gene transfer increases the drug resistance of Aeromonas veronii.

ABSTRACT: Aeromonas veronii is an opportunistic pathogen that affects both fish and mammals, including humans, leading to bacteraemia, sepsis, meningitis and even death. The increasing virulence and drug resistance of A. veronii are of significant concern and pose a severe risk to public safety. The Type I restriction-modification (RM) system, which functions as a bacterial defence mechanism, can influence gene expression through DNA methylation. However, little research has been conducted to explore its origin, evolutionary path, and relationship to virulence and drug resistance in A. veronii. In this study, we analysed the pan-genome of 233 A. veronii strains, and the results indicated that it was 'open', meaning that A. veronii has acquired additional gen

SUBMITTER: Ma J 

PROVIDER: S-EPMC10569733 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature