Analysis of Escherichia coli O157 strains in cattle and humans between Scotland and England & Wales: implications for human health.

ABSTRACT: For the last two decades, the human infection frequency of Escherichia coli O157 (O157) in Scotland has been 2.5-fold higher than in England and Wales. Results from national cattle surveys conducted in Scotland and England and Wales in 2014/2015 were combined with data on reported human clinical cases from the same time frame to determine if strain differences in national populations of O157 in cattle could be associated with higher human infection rates in Scotland. Shiga toxin subtype (Stx) and phage type (PT) were examined within and between host (cattle vs human) and nation (Scotland vs England and Wales). For a subset of the strains, whole genome sequencing (WGS) provided further insights into geographical and host association. All three major O157 lineages (I, II, I/II) and mo

SUBMITTER: Chase-Topping M 

PROVIDER: S-EPMC10569735 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature