Pulmonary, inflammatory, and oxidative effects of indoor nitrogen dioxide in patients with COPD.

ABSTRACT:

Introduction

Indoor nitrogen dioxide (NO₂) sources include gas heating, cooking, and infiltration from outdoors. Associations with pulmonary function, systemic inflammation, and oxidative stress in patients with chronic obstructive pulmonary disease (COPD) are uncertain.

Methods

We recruited 144 COPD patients at the VA Boston Healthcare System between 2012 and 2017. In-home NO₂ was measured using an Ogawa passive sampling badge for a week seasonally followed by measuring plasma biomarkers of systemic inflammation (C-reactive protein [CRP] and interleukin-6 [IL-6]), urinary oxidative stress biomarkers (8-hydroxy-2'deoxyguanosine [8-OHdG] and malondialdehyde [MDA]), and pre- and postbronchodilator spirometry. Linear mixed effects regression with a random

SUBMITTER: McHugh EG 

PROVIDER: S-EPMC10569754 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature