Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes.

ABSTRACT: Mammalian mitochondrial respiratory chain (MRC) complexes are able to associate into quaternary structures named supercomplexes (SCs), which normally coexist with non-bound individual complexes. The functional significance of SCs has not been fully clarified and the debate has been centered on whether or not they confer catalytic advantages compared with the non-bound individual complexes. Mitochondrial respiratory chain organization does not seem to be conserved in all organisms. In fact, and differently from mammalian species, mitochondria from Drosophila melanogaster tissues are characterized by low amounts of SCs, despite the high metabolic demands and MRC activity shown by these mitochondria. Here, we show that attenuating the biogenesis of individual respiratory chain complexe

SUBMITTER: Brischigliaro M 

PROVIDER: S-EPMC10569793 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature