Effects of Chrysin on Oral Squamous Cell Carcinoma In Vitro.

ABSTRACT:

Objective

 Chrysin is a hydroxylated flavonoid derived from "propolis or bee glue," a natural product. Previous research on chrysin's biological functions, including anticancer activity, had been reported. However, chrysin's effect on oral squamous cell carcinoma (OSCC) is still scarce. This article aimed to test the cytotoxicity, antiproliferative, antimigration, anti-invasion, and apoptotic effects of purified chrysin in two OSCC cell lines, HSC4 and SCC25.

Materials and methods

 The malignant phenotype was assessed using cell proliferation, wound healing, and transwell assays. Cell apoptosis was determined using flow cytometry. The positive control was OSCC cells treated with cisplatin, and the negative control was OSCC cells incubated with 0.1% dimethyl sulfoxide.

Res

SUBMITTER: Puengsurin D 

PROVIDER: S-EPMC10569856 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature