DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation.

ABSTRACT: Faithful cell division is the basis for the propagation of life and DNA replication must be precisely regulated. DNA replication stress is a prominent endogenous source of genome instability that not only leads to ageing, but also neuropathology and cancer development in humans. Specifically, the issues of how vertebrate cells select and activate origins of replication are of importance as, for example, insufficient origin firing leads to genomic instability and mutations in replication initiation factors lead to the rare human disease Meier-Gorlin syndrome. The mechanism of origin activation has been well characterised and reconstituted in yeast, however, an equal understanding of this process in higher eukaryotes is lacking. The firing of replication origins is driven by S-phase kinases

SUBMITTER: Kingsley G 

PROVIDER: S-EPMC10570026 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature