Application of the D₃ -creatine muscle mass assessment tool to a geriatric weight loss trial: A pilot study.

ABSTRACT:

Background

Traditionally, weight loss (WL) trials utilize dual energy X-ray absorptiometry (DXA) to measure lean mass. This method assumes lean mass, as the sum of all non-bone and non-fat tissue, is a reasonable proxy for muscle mass. In contrast, the D₃ -creatine (D₃ Cr) dilution method directly measures whole body skeletal muscle mass, although this method has yet to be applied in the context of a geriatric WL trial. The purpose of this project was to (1) describe estimates of change and variability in D₃ Cr muscle mass in older adults participating in an intentional WL intervention and (2) relate its change to other measures of body composition as well as muscle function and strength.

Methods

The INVEST in Bone Health trial (NCT04076618),

SUBMITTER: Beavers KM 

PROVIDER: S-EPMC10570063 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature