Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study.

ABSTRACT:

Background

Observational studies have demonstrated a strong bidirectional association between frailty and depression, but it remains unclear whether this association reflects causality. This study aimed to examine the bidirectional causal relationship between frailty and depression.

Methods

Using genome-wide association study summary data, two-sample Mendelian randomization was performed to test for the potential bidirectional causality between frailty, as defined by both the frailty index and the frailty phenotype, and depression. Several frailty-related traits were additionally investigated, including weaker hand grip strength, slower walking pace and physical inactivity. Findings were replicated using an independent depression data source and verified using multiple sensi

SUBMITTER: Zhu J 

PROVIDER: S-EPMC10570069 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature