Prevotella copri alleviates sarcopenia via attenuating muscle mass loss and function decline.

ABSTRACT:

Background

The gut microbiome and fecal metabolites have been found to influence sarcopenia, but whether there are potential bacteria that can alleviate sarcopenia has been under-investigated, and the molecular mechanism remains unclear.

Methods

To investigate the relationships between the gut microbiome, fecal metabolites and sarcopenia, subjects were selected from observational multi-ethnic study conducted in Western China. Sarcopenia was diagnosed according to the criteria of the Asian Working Group for Sarcopenia 2014. The gut microbiome was profiled by shotgun metagenomic sequencing. Untargeted metabolomic analysis was performed to analyse the differences in fecal metabolites. We investigated bacterium with the greatest relative abundance difference between healthy indi

SUBMITTER: Liu X 

PROVIDER: S-EPMC10570070 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature