Protein intake in cancer: Does it improve nutritional status and/or modify tumour response to chemotherapy?

ABSTRACT:

Background

Combating malnutrition and cachexia is a core challenge in oncology. To limit muscle mass loss, the use of proteins in cancer is encouraged by experts in the field, but it is still debated due to their antagonist effects. Indeed, a high protein intake could preserve lean body mass but may promote tumour growth, whereas a low-protein diet could reduce tumour size but without addressing cachexia. Here we used a realistic rodent model of cancer and chemotherapy to evaluate the influence of different protein intakes on cachexia, tumour response to chemotherapy and immune system response. The goal is to gain a closer understanding of the effect of protein intake in cancer patients undergoing chemotherapy.

Methods

Female Fischer 344 rats were divided into six groups: fi

SUBMITTER: Boutiere M 

PROVIDER: S-EPMC10570073 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature