Cdon ablation in motor neurons causes age-related motor neuron degeneration and impaired sciatic nerve repair.

ABSTRACT:

Background

The functional deterioration and loss of motor neurons are tightly associated with degenerative motor neuron diseases and aging-related muscle wasting. Motor neuron diseases or aging-related muscle wasting in turn contribute to increased risk of adverse health outcomes in the elderly. Cdon (cell adhesion molecule-downregulated oncogene) belongs to the immunoglobulin superfamily of cell adhesion molecule and plays essential roles in multiple signalling pathways, including sonic hedgehog (Shh), netrin, and cadherin-mediated signalling. Cdon as a Shh coreceptor plays a critical role in motor neuron specification during embryonic development. However, its role in adult motor neuron function is unknown.

Methods

Hb9-Cre recombinase-driven motor neuron-specific Cdon defi

SUBMITTER: Kim S 

PROVIDER: S-EPMC10570074 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature