Short-term disuse does not affect postabsorptive or postprandial muscle protein fractional breakdown rates.

ABSTRACT:

Background

The decline in postabsorptive and postprandial muscle protein fractional synthesis rates (FSR) does not quantitatively account for muscle atrophy during uncomplicated, short-term disuse, when atrophy rates are the highest. We sought to determine whether 2 days of unilateral knee immobilization affects mixed muscle protein fractional breakdown rates (FBR) during postabsorptive and simulated postprandial conditions.

Methods

Twenty-three healthy, male participants (age: 22 ± 1 year; height: 179 ± 1 cm; body mass: 73.4 ± 1.5 kg; body mass index 22.8 ± 0.5 kg·m^-2 ) took part in this randomized, controlled study. After 48 h of unilateral knee immobilization, primed continuous intravenous l-[¹⁵ N]-phenylalanine and l-[ring-² H₅

SUBMITTER: Pavis GF 

PROVIDER: S-EPMC10570083 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature