Impaired skeletal muscle health in Parkinsonian syndromes: clinical implications, mechanisms and potential treatments.

ABSTRACT: There is increasing evidence that neurodegenerative disorders including the Parkinsonian syndromes are associated with impaired skeletal muscle health, manifesting as wasting and weakness. Many of the movement problems, lack of muscle strength and reduction in quality of life that are characteristic of these syndromes can be attributed to impairments in skeletal muscle health, but this concept has been grossly understudied and represents an important area of unmet clinical need. This review describes the changes in skeletal muscle health in idiopathic Parkinson's disease and in two atypical Parkinsonian syndromes, the most aggressive synucleinopathy multiple system atrophy, and the tauopathy progressive supranuclear palsy. The pathogenesis of the skeletal muscle changes is described, inclu

SUBMITTER: Murphy KT 

PROVIDER: S-EPMC10570091 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature